Article
An ATG repeat in the 3'-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance.
The Journal of clinical endocrinology and metabolism - 1 Sept 2002
Pizzuti Antonio, Argiolas Alessandra, Di Paola Rosa, Baratta Roberto, Rauseo Anna, Bozzali Maura, Vigneri Riccardo, Dallapiccola Bruno, Trischitta Vincenzo, Frittitta Lucia
Abstract excerpt
Resistin is overexpressed in human adipose tissue of obese individuals and is likely to modulate insulin sensitivity. Resistin is, therefore, a candidate gene for insulin resistance. We searched for polymorphisms in the resistin gene by single strand conformation polymorphism and direct sequencing. An ATG triplet repeat in the 3'-untranslated region was identified and considered for association with insulin...
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