Article
Genetic variants at the resistin locus and risk of type 2 diabetes in Caucasians.
The Journal of clinical endocrinology and metabolism - 1 Sept 2002
Ma Xiaowei, Warram James H, Trischitta Vincenzo, Doria Alessandro
Abstract excerpt
Resistin is a newly identified hormone secreted by adipocytes that inhibits insulin action on peripheral tissues. The aim of our study was to investigate whether genetic variability at this locus is associated with the risk of type 2 diabetes. By sequencing 32 subjects with type 2 diabetes, we identified 8 single nucleotide polymorphisms (SNPs) in the 5'-flanking region and introns of the resistin gene. Allele...
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