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Article

Impact of the presence of paralogs on sequence divergence in a set of mouse-human orthologs.

Genome research - 1 Sept 2002

Nembaware Victoria, Crum Karen, Kelso Janet, Seoighe Cathal

Abstract excerpt

Using a large set of orthologous human and mouse gene pairs, we have characterized genes that have been retained in duplicate in human over timescales comparable to the time of speciation of human and mouse. Orthologous gene pairs for which a paralogous gene has been present for much or all of the time since speciation show an increased rate of nonsynonymous substitution. We have related rate of divergence to...

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Identifiers

PMID: 12213774
DOI: 10.1101/gr.270902
PMCID: PMC186655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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