Article

Humanization of yeast genes with multiple human orthologs reveals principles of functional divergence between paralogs

2019-06-13

Abstract excerpt

Despite over a billion years of evolutionary divergence, several thousand human genes possess clearly identifiable orthologs in yeast, and many have undergone lineage-specific duplications in one or both lineages. The ortholog conjecture postulates that orthologous genes between species retain ancestral functions despite divergence over vast timescales, but duplicated genes will be free to diverge in function. How...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e737c2a-3827-5aef-8f2a-68f9a1944aec
DOI: 10.1101/668335

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Humanization of yeast genes with multiple human orthologs reveals principles of functional divergence between paralogsDOI 10.1101/668335Read

Identifying pathogenicity of human variants via paralog-based yeast complementation.Semantic proximity Read

Functional partitioning of yeast co-expression networks after genome duplication.Semantic proximity Read

Human monogenic disease genes have frequently functionally redundant paralogs.Semantic proximity Read

Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution.Semantic proximity Read

Proteins with amino acid repeats constitute rapidly evolvable and human-specific essentialomeSemantic proximity Read

On the scope and limitations of baker’s yeast as a model organism for studying human tissue-specific pathwaysSemantic proximity Read

Rapid and asymmetric divergence of duplicate genes in the human gene coexpression network.Semantic proximity Read

Co-translational assembly promotes functional diversification of paralogous proteinsSemantic proximity Read

New insights on human essential genes based on integrated analysisSemantic proximity Read

Co-occurrence of essential gene dispensability and bypass suppressor mutations across speciesSemantic proximity Read

Conservation of the genetic interaction network between two yeast speciesSemantic proximity Read

An orthologous gene coevolution network provides insight into eukaryotic cellular and genomic structure and functionSemantic proximity Read