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Article

On the origins of Mendelian disease genes in man: the impact of gene duplication.

Molecular biology and evolution - 1 Jan 2012

Dickerson Jonathan E, Robertson David L

Abstract excerpt

Over 3,000 human diseases are known to be linked to heritable genetic variation, mapping to over 1,700 unique genes. Dating of the evolutionary age of these disease-associated genes has suggested that they have a tendency to be ancient, specifically coming into existence with early metazoa. The approach taken by past studies, however, assumes that the age of a disease is the same as the age of its common...

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Identifiers

PMID: 21705381
DOI: 10.1093/molbev/msr111
PMCID: PMC3709195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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