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Article

Pattern of divergence of amino acid sequences encoded by paralogous genes in human and pufferfish.

Molecular phylogenetics and evolution - 1 Jul 2004

Hughes Austin L, Friedman Robert

Abstract excerpt

We used phylogenetic analyses of protein families containing two or more pairs of orthologues in the genomes of human and pufferfish (Takifugu rubripes) to test the hypothesis that these sequences show a strong signal of polyploidization events hypothesized to have occurred early in vertebrate history. In order to test for evidence of two distinct rounds of polyploidization (the 2R hypothesis), we compared the...

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PMID: 15186818
DOI: 10.1016/j.ympev.2003.12.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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