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Article

Duplicated genes evolve slower than singletons despite the initial rate increase.

BMC evolutionary biology - 6 Jul 2004

Jordan I King, Wolf Yuri I, Koonin Eugene V

Abstract excerpt

BACKGROUND: Gene duplication is an important mechanism that can lead to the emergence of new functions during evolution. The impact of duplication on the mode of gene evolution has been the subject of several theoretical and empirical comparative-genomic studies. It has been shown that, shortly after the duplication, genes seem to experience a considerable relaxation of purifying selection. RESULTS: Here we...

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PMID: 15238160
DOI: 10.1186/1471-2148-4-22
PMCID: PMC481058

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