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Article

Calpain inhibitors: a treatment for Alzheimer's disease.

Journal of molecular neuroscience : MN - 1 Jan 2000

Di Rosa Gabriella, Odrijin Tatjana, Nixon Ralph A, Arancio Ottavio

Abstract excerpt

Activation of the calpain system might contribute to the impairment of synaptic transmission in Alzheimer's disease (AD) (Liu et al., 1999; Rapoport, 1999; Selkoe, 1994). Calpains regulate the function of many proteins by limited proteolysis and initiate the complete degradation of other proteins. In particular, they modulate processes that govern the function and metabolism of proteins key to the pathogenesis of...

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Source

Identifiers

PMID: 12212771
DOI: 10.1007/s12031-002-0024-4

Genes

APP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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