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Article

Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Sept 2016

Saito Takashi, Matsuba Yukio, Yamazaki Naomi, Hashimoto Shoko, Saido Takaomi C

Abstract excerpt

UNLABELLED: Intraneuronal calcium stimulates the calpain-dependent conversion of p35 to p25, a CDK5 activator. It is widely believed that amyloid β peptide (Aβ) induces this conversion that, in turn, has an essential role in Alzheimer's disease pathogenesis. However, in vivo studies on p25 generation used transgenic mice overexpressing mutant amyloid precursor protein (APP) and presenilin (PS). Here, using single...

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Source

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Identifiers

PMID: 27656030
DOI: 10.1523/JNEUROSCI.1907-16.2016
PMCID: PMC5030353

Genes

APP
CDK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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