Article
Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells.
International journal of cancer - 1 Sept 2002
Scotlandi Katia, Avnet Sofia, Benini Stefania, Manara Maria Cristina, Serra Massimo, Cerisano Vanessa, Perdichizzi Stefania, Lollini Pier-Luigi, De Giovanni Carla, Landuzzi Lorena, Picci Piero
Abstract excerpt
IGF-IR plays an essential role in the establishment and maintenance of the transformed phenotype of ES cells and interference with the IGF-IR pathways causes reversal of the malignant potential of this neoplasm. In this report, we stably transfected a dominant negative IGF-IR expression plasmid in an ES cell line to determine the effectiveness of this strategy against the in vitro and in vivo growth of ES cells....
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