Article
Transforming growth factor beta1 gene polymorphism in patients with systemic sclerosis.
The Journal of rheumatology - 1 Jul 2003
Sugiura Yoshiki, Banno Shogo, Matsumoto Yoshifuji, Niimi Takashi, Yoshinouchi Takeo, Hayami Yoshihito, Naniwa Taio, Ueda Ryuzo
Abstract excerpt
OBJECTIVE: To determine whether transforming growth factor beta1 (TGFbeta1) gene DNA polymorphism is associated with pathogenesis in the fibrosis of patients with systemic sclerosis (SSc). METHODS: Eighty-seven Japanese patients with SSc including 30 with diffuse type and 57 with limited type together with 110 unrelated controls were investigated. Pulmonary fibrosis was determined in 34 SSc patients using...
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