Article
Single-nucleotide polymorphisms of transforming growth factor-beta1 gene in Taiwanese patients with systemic lupus erythematosus.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi - 1 Jun 2004
Lu Ling-Ying, Cheng He-Hsiung, Sung Ping-Kuang, Yeh Jeng-Jung, Shiue Yow-Ling, Chen Angela
Abstract excerpt
Transforming growth factor-beta1 (TGF-beta1) is involved in the generation of CD8+ T suppressor cells, natural killer (NK) cells and regulatory T (Th3) cells for down-regulatory effects on antibody production. We studied TGF-beta1 activity in patients with systemic lupus erythematosus (SLE) to try to clarify whether the dysregulation by TGF-beta1 is genetically determined. Sera from 55 patients with clinically...
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