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Article

Studies of penetrance and anticipation in five autosomal-dominant restless legs syndrome pedigrees.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 1999

Lazzarini A, Walters A S, Hickey K, Coccagna G, Lugaresi E, Ehrenberg B L, Picchietti D L, Brin M F, Stenroos E S, Verrico T, Johnson W G

Abstract excerpt

Restless legs syndrome (RLS) can occur with an autosomal-dominant mode of inheritance. To determine if there are distinguishing features of RLS pedigrees which might clarify molecular mechanisms of pathogenesis, five pedigrees with 81 affected members were analyzed for age of onset, sex ratio, and transmission pattern. One-factor analysis of variance of ages of onset between generations was carried out, and...

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Identifiers

PMID: 9918352
DOI: 10.1002/1531-8257(199901)14:1<111::aid-mds1018>3.0.co;2-9

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