Studies of penetrance and anticipation in five autosomal-dominant restless legs syndrome pedigrees.

doi:10.1002/1531-8257(199901)14:1<111::aid-mds1018>3.0.co;2-9

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Article

Studies of penetrance and anticipation in five autosomal-dominant restless legs syndrome pedigrees.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 1999

Lazzarini A, Walters A S, Hickey K, Coccagna G, Lugaresi E, Ehrenberg B L, Picchietti D L, Brin M F, Stenroos E S, Verrico T, Johnson W G

Abstract excerpt

Restless legs syndrome (RLS) can occur with an autosomal-dominant mode of inheritance. To determine if there are distinguishing features of RLS pedigrees which might clarify molecular mechanisms of pathogenesis, five pedigrees with 81 affected members were analyzed for age of onset, sex ratio, an...

Topics

Adolescent
Adult
Aged
Anticipation, Genetic
Child
Child, Preschool
Chromosome Aberrations
Chromosome Disorders
Female
Genes, Dominant
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant

Male

Middle Aged

Models, Genetic

Pedigree

Penetrance

Source

Open in PubMed

Identifiers

PMID: 9918352
DOI: 10.1002/1531-8257(199901)14:1<111::aid-mds1018>3.0.co;2-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9918352-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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