Article
Segregation analysis of restless legs syndrome: possible evidence for a major gene in a family study using blinded diagnoses.
Human heredity - 1 Jan 2006
Mathias Rasika A, Hening Wayne, Washburn Mystinna, Allen Richard P, Lesage Suzanne, Wilson Alexander F, Earley Christopher J
Abstract excerpt
OBJECTIVE: The objective of this study was to ascertain the most likely inheritance pattern of restless legs syndrome (RLS) using segregation analysis. METHODS: Probands were RLS patients presenting to the Neurology and Sleep clinics of the Johns-Hopkins Bayview medical center with willing first and second degree relatives. Blinded diagnosis was made in those who exhibited the four diagnostic features of RLS....
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