Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The influence of PON1 192 polymorphism on endothelial function in diabetic subjects with or without hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Mar 2008

Irace Concetta, Cortese Claudio, Fiaschi Elio, Scavelli Faustina, Liberatoscioli Laura, Federici Giorgio, Gnasso Agostino

Abstract excerpt

Hypertension and type 2 diabetes mellitus (T2DM) cause endothelial dysfunction probably through increased oxidant stress. Paraoxonase (PON1) is an high-density lipoprotein (HDL)-linked anti-oxidant enzyme whose capacity is influenced by a genetic polymorphism at codon 192. In the present study we have investigated the role of PON1 polymorphism on endothelial function in subjects with T2DM with or without...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryldialkylphosphatase
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brachial Artery

Share to Diabetes Mellitus, Type 2

Share to Endothelium, Vascular

Share to Hypertension

Share to Oxidative Stress

Share to Vasodilation

Source

Identifiers

PMID: 18497471
DOI: 10.1291/hypres.31.507

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The influence of PON1 192 polymorphism on endothelial function in diabetic subjects with or without hypertension.PMID 18497471Read ↗

Paraoxonase 1 192 Gln/Arg gene polymorphism and cerebrovascular disease: interaction with type 2 diabetes.Semantic proximity Read ↗

Gln-Arg192 polymorphism of paraoxonase 1 is associated with carotid intima-media thickness in patients of type 2 diabetes mellitus of Chinese.Semantic proximity Read ↗

Paraoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus.Semantic proximity Read ↗

The Arg allele in position 192 of PON1 is associated with carotid atherosclerosis in subjects with elevated HDLs.Semantic proximity Read ↗

Importance of paraoxonase 1 (PON1) as an antioxidant and antiatherogenic enzyme in the cardiovascular complications of type 2 diabetes: Genotypic and phenotypic evaluation.Semantic proximity Read ↗

Influence of the human paraoxonase polymorphism (PON1 192) on the carotid-wall thickening in a healthy population.Semantic proximity Read ↗

Paraoxonase 1 Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus.Semantic proximity Read ↗

Paraoxonase-1 activity modulates endothelial function in patients with peripheral arterial disease.Semantic proximity Read ↗

Paraoxonase1-192 polymorphism modulates the nonfatal myocardial infarction risk associated with decreased HDLs.Semantic proximity Read ↗

The gln-Arg192 polymorphism of human paraoxonase gene is not associated with coronary artery disease in italian patients.Semantic proximity Read ↗

Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type I diabetes mellitus.Semantic proximity Read ↗

p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.