Article
Drosophila damage-specific DNA-binding protein 1 (D-DDB1) is controlled by the DRE/DREF system.
Nucleic acids research - 1 Sept 2002
Takata Kei-ichi, Ishikawa Gen, Hirose Fumiko, Sakaguchi Kengo
Abstract excerpt
We succeeded in cloning the gene, termed d-ddb1, for a Drosophila homolog of the p127 subunit of the human damage-specific DNA-binding protein, thought to recognize (6-4) photoproducts and related structures. In Drosophila, the gene product (D-DDB1) also appeared to play a role as a repair factor, d-ddb1 knockout Kc cells generated with a RNAi method being sensitive to UV. In addition, UV or methyl...
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