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Article

DDB Accumulates at DNA Damage Sites Immediately after UV Irradiation and Directly Stimulates Nucleotide Excision Repair

1 Jan 2002

Abstract excerpt

Damaged DNA-binding protein, DDB, is a heterodimer of p127 and p48 with a high specificity for binding to several types of DNA damage. Mutations in the p48 gene that cause the loss of DDB activity were found in a subset of xeroderma pigmentosum complementation group E (XP-E) patients and have linked to the deficiency in global genomic repair of cyclobutane pyrimidine dimers (CPDs) in these cells. Here we show...

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Identifiers

PMID: 11705987
DOI: 10.1074/jbc.c100610200

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Research trail→

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DDB Accumulates at DNA Damage Sites Immediately after UV Irradiation and Directly Stimulates Nucleotide Excision RepairPMID 11705987Read ↗

Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation.Semantic proximity Read ↗

True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product.Semantic proximity Read ↗

Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation.Semantic proximity Read ↗

The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription.Semantic proximity Read ↗

Expression of the <i>p48</i> xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repairSemantic proximity Read ↗

The DDB2 nucleotide excision repair gene product p48 enhances global genomic repair in p53 deficient human fibroblastsSemantic proximity Read ↗

p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity.Semantic proximity Read ↗

DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.Semantic proximity Read ↗

Every protagonist has a sidekick: Structural aspects of human xeroderma pigmentosum-binding proteins in nucleotide excision repair.Semantic proximity Read ↗

Impaired regulation of tumor suppressor p53 caused by mutations in the xeroderma pigmentosum DDB2 gene: mutual regulatory interactions between p48(DDB2) and p53.Semantic proximity Read ↗

Xeroderma Pigmentosum C (XPC) Mutations in Primary Fibroblasts Impair Base Excision Repair Pathway and Increase Oxidative DNA DamageSemantic proximity Read ↗

Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype.Semantic proximity Read ↗

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