Article
Novel promiscuous HLA-DQ HIV Nef peptide that induces IFN-gamma-producing memory CD4+ T cells.
Clinical and experimental immunology - 1 Sept 2002
Pancré V, Georges B, Angyalosi G, Castelli F, Delanoye A, Delacre M, Hachulla E, Maillere B, Bouzidi A, Auriault C
Abstract excerpt
We describe the highly conserved sequence 56-68 of the HIV Nef protein as the first promiscuous HLA-DQ HIV-derived peptide. The Nef peptide exhibits an albeit rare capacity to bind 6 different HLA-DQ molecules whereas no binding is observed with the 10 HLA-DR molecules tested. In agreement with these data, after immunization with the Nef peptide, HLA-DQ transgenic Abeta degrees mice display a vigorous cellular...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Clone Cells
- Conserved Sequence
- Gene Products, nef
- HIV
- HLA-DQ Antigens
- Histocompatibility Antigens Class II
- Humans
- Immunoglobulin Variable Region
- Immunologic Memory