Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel promiscuous HLA-DQ HIV Nef peptide that induces IFN-gamma-producing memory CD4+ T cells.

Clinical and experimental immunology - 1 Sept 2002

Pancré V, Georges B, Angyalosi G, Castelli F, Delanoye A, Delacre M, Hachulla E, Maillere B, Bouzidi A, Auriault C

Abstract excerpt

We describe the highly conserved sequence 56-68 of the HIV Nef protein as the first promiscuous HLA-DQ HIV-derived peptide. The Nef peptide exhibits an albeit rare capacity to bind 6 different HLA-DQ molecules whereas no binding is observed with the 10 HLA-DR molecules tested. In agreement with these data, after immunization with the Nef peptide, HLA-DQ transgenic Abeta degrees mice display a vigorous cellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Products, nef
Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Immunologic Memory

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Receptors, Antigen, T-Cell

Share to Th1 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 12197883
DOI: 10.1046/j.1365-2249.2002.01934.x
PMCID: PMC1906467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel promiscuous HLA-DQ HIV Nef peptide that induces IFN-gamma-producing memory CD4+ T cells.PMID 12197883Read ↗

Short communication: HIV-1 Nef protein carries multiple epitopes suitable for induction of cellular immunity for an HIV vaccine in Africa.Semantic proximity Read ↗

In vivo priming of HIV-specific CTLs determines selective cross-reactive immune responses against poorly immunogenic HIV-natural variants.Semantic proximity Read ↗

Autologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptides.Semantic proximity Read ↗

CTL-mediated selective pressure influences dynamic evolution and pathogenic functions of HIV-1 Nef.Semantic proximity Read ↗

ART-Treated Patients Exhibit an Adaptive Immune Response against the HFVAC Peptides, a Potential HIV-1 Therapeutic Vaccine (Provir/Latitude45 Study).Semantic proximity Read ↗

HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognitionSemantic proximity Read ↗

Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein.Semantic proximity Read ↗

HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity.Semantic proximity Read ↗

HLA Class I Binding Promiscuity of the CD8 T-Cell Epitopes of Human Papillomavirus Type 16 E6 ProteinSemantic proximity Read ↗

Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides.Semantic proximity Read ↗

HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele.Semantic proximity Read ↗

GP41 peptide biomarkers of chronicity of HIV infection identified through PepScan Epitope ApproachSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.