Article
Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides.
Immunity - 1 Dec 1994
Alexander J, Sidney J, Southwood S, Ruppert J, Oseroff C, Maewal A, Snoke K, Serra H M, Kubo R T, Sette A
Abstract excerpt
Pan DR-binding peptides engineered by introducing anchor residues for different DR motifs within a polyalanine backbone bound 10 of 10 DR molecules tested, with affinities, in most cases, in the nanomolar range. Because of the small methyl group exposed for T cell recognition, these peptides were...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Binding Sites
- Cell Division
- Cross Reactions
- HLA-DR Antigens
- Humans
- Leukocytes, Mononuclear
- Lymphocyte Activation
- Mice