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Article

Extra axonal neurofilaments do not exacerbate disease caused by mutant Cu,Zn superoxide dismutase.

Neurobiology of disease - 1 Aug 2000

Couillard-Després S, Meier J, Julien J P

Abstract excerpt

A recent report by T. L. Williamson et al. (1998, Proc. Natl. Acad. Sci. USA 95, 9631-9636) showed that disease caused by expression of mutant Cu,Zn superoxide dismutase (SOD1) in mice was slowed down by disruption of the neurofilament light (NF-L) gene. This led to the conclusion that decreasing the axonal amount of neurofilaments reduces the vulnerability of motor neurons to toxicity mediated by mutant SOD1. We...

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Source

Identifiers

PMID: 10964615
DOI: 10.1006/nbdi.2000.0296

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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