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Cytogenetics and molecular genetics of acute lymphoblastic leukemia

1 Jun 2002

Abstract excerpt

An important factor in the diagnosis of acute lymphoblastic leukemia (ALL) is that karyotype is an independent prognostic indicator, with an impact on the choice of treatment. Outcome is related to the number of chromosomes. For example, high hyperdiploidy (51-65 chromosomes) is associated with a good prognosis, whereas patients with near haploidy (23-29 chromosomes) have a poor outcome. The discovery of...

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PMID: 12196211
DOI: 10.1046/j.1468-0734.2002.00069.x

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