Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling.

Current biology : CB - 20 Aug 2002

Fan Qi-Wen, Zhang Chao, Shokat Kevan M, Weiss William A

Abstract excerpt

BACKGROUND: Our understanding of protein kinase inhibition in the treatment of cancer is clearly limited by the lack of inhibitors that selectively block a single kinase implicated in neoplastic transformation. One approach to developing specific inhibitors is to engineer in protein kinases silent mutations that allow selective inhibition while retaining kinase activity. Because it is implicated in a large number...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Cell Size
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclins

Share to Genes, erbB-1

Share to Naphthalenes

Share to Oncogene Protein pp60(v-src)

Share to Proto-Oncogene Proteins c-raf

Source

Identifiers

PMID: 12194819
DOI: 10.1016/s0960-9822(02)01070-9

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling.PMID 12194819Read ↗

Transformation of mammalian cells by constitutively active MAP kinase kinase.Semantic proximity Read ↗

Design of allele-specific inhibitors to probe protein kinase signaling.Semantic proximity Read ↗

Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.Semantic proximity Read ↗

Interfering with RAS-effector protein interactions prevent RAS-dependent tumour initiation and causes stop-start control of cancer growth.Semantic proximity Read ↗

Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.Semantic proximity Read ↗

Protein phosphatase 1alpha activity prevents oncogenic transformation.Semantic proximity Read ↗

Induction of neoplastic progression in Syrian hamster embryo cells treated with protein phosphatase inhibitors.Semantic proximity Read ↗

EGFR-independent activation of ERK1/2 mediates growth inhibition by a PTPase antagonizing K-vitamin analog.Semantic proximity Read ↗

Increased susceptibility of ras-transformed cells to phenylacetate is associated with inhibition of p21ras isoprenylation and phenotypic reversion.Semantic proximity Read ↗

Reversible tumorigenesis induced by deficiency of vasodilator-stimulated phosphoprotein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.