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Article

Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle response.

Molecular and cellular biology - 1 Sept 2002

Wang Xiaozhong, Su Hong, Copenhagen Leslie D, Vaishnav Sukishi, Pieri Fredalina, Shope Cynthia Do, Brownell William E, De Biasi Mariella, Paylor Richard, Bradley Allan

Abstract excerpt

Corticotropin-releasing hormone (Crh) plays an important role in modulating physiological and behavioral responses to stress. Its actions are mediated through two receptors, Crhr1 and Crhr2. Urocortin (Ucn), a Crh-related neuropeptide and the postulated endogenous ligand for Crhr2, is a potential mediator of stress responses. We generated Ucn-deficient mice using embryonic stem cell technology to determine its...

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Identifiers

PMID: 12192058
DOI: 10.1128/MCB.22.18.6605-6610.2002
PMCID: PMC135620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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