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Article

Adrenal and Ovarian Phenotype of a Tissue-Specific Urocortin 2-Overexpressing Mouse Model.

Endocrinology - 1 Jul 2015

Spyroglou Ariadni, Riester Anna, Mueller-Peltzer Katharina, Lu Ailing, Rohde Juliane, Hantel Constanze, Kuehne Claudia, Kulle Alexandra, Riepe Felix, Deussing Jan M, Beuschlein Felix

Abstract excerpt

Urocortin 2 (UCN2) is a neuropeptide of the CRH family, involved in homeostatic mechanisms, the stress response, and control of anxiety. To elucidate the effects of UCN2 on steroidogenesis, we developed a mouse model that allows a Cre recombinase-determined conditional overexpression of UCN2 (UCN2-COE). In these mice SF1-Cre-driven overexpression of UCN2 was restricted to the adrenal glands, gonads, and parts of...

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Source

Identifiers

PMID: 25942073
DOI: 10.1210/en.2014-1971

Genes

UCN2
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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