Article
Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits.
Molecular psychiatry - 1 Apr 2010
Neufeld-Cohen A, Evans A K, Getselter D, Spyroglou A, Hill A, Gil S, Tsoory M, Beuschlein F, Lowry C A, Vale W, Chen A
Abstract excerpt
The urocortin (Ucn) family of neuropeptides is suggested to be involved in homeostatic coping mechanisms of the central stress response through the activation of corticotropin-releasing factor receptor type 2 (CRFR2). The neuropeptides, Ucn1 and Ucn2, serve as endogenous ligands for the CRFR2, which is highly expressed by the dorsal raphe serotonergic neurons and is suggested to be involved in regulating major...
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