Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction.

doi:10.1046/j.1365-2125.2003.01824.x

Article

Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction.

British journal of clinical pharmacology - 1 Jul 2003

Rengelshausen Jens, Göggelmann Christoph, Burhenne Jürgen, Riedel Klaus-Dieter, Ludwig Jochen, Weiss Johanna, Mikus Gerd, Walter-Sack Ingeborg, Haefeli Walter E

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AIMS: A clinically important interaction between the cardiac glycoside digoxin and the antibiotic clarithromycin has been suggested in earlier reports. The aim of this study was to investigate the extent of the interaction and the relative contribution of different mechanisms. METHODS: In a rando...

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Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction.

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