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Article

Zidovudine–didanosine coexposure potentiates DNA incorporation of zidovudine and mutagenesis in human cells

31 Oct 2000

Abstract excerpt

Drug combinations that include nucleoside reverse transcriptase inhibitors (NRTIs) are remarkably effective in preventing maternal-viral transmission of HIV during pregnancy. However, there may be potential long-term risks for children exposed in utero. Examination of the genotoxic and mutagenic effects of two NRTIs, zidovudine [AZT (3'-azido-3'-deoxythymidine)] and didanosine [ddI (2',3'-dideoxyinosine)], in...

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PMID: 11058153
DOI: 10.1073/pnas.220203197

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