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Article

Interference between D30N and L90M in selection and development of protease inhibitor-resistant human immunodeficiency virus type 1.

Antimicrobial agents and chemotherapy - 1 Mar 2002

Sugiura Wataru, Matsuda Zene, Yokomaku Yoshiyuki, Hertogs Kurt, Larder Brendan, Oishi Tsuyoshi, Okano Aiko, Shiino Teiichirou, Tatsumi Masashi, Matsuda Masakazu, Abumi Hanae, Takata Noboru, Shirahata Satoshi, Yamada Kaneo, Yoshikura Hiroshi, Nagai Yoshiyuki

Abstract excerpt

We studied the evolutionary relationships between the two protease inhibitor (PI) resistance mutations, D30N and L90M, of human immunodeficiency virus type 1 (HIV-1). The former is highly specific for nelfinavir resistance, while the latter is associated with resistance to several PIs, including...

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Identifiers

PMID: 11850252
DOI: 10.1128/AAC.46.3.708-715.2002
PMCID: PMC127489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11850252-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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