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Article

Notch1 control of oligodendrocyte differentiation in the spinal cord.

The Journal of cell biology - 19 Aug 2002

Genoud Stephane, Lappe-Siefke Corinna, Goebbels Sandra, Radtke Freddy, Aguet Michel, Scherer Steven S, Suter Ueli, Nave Klaus-Armin, Mantei Ned

Abstract excerpt

We have selectively inhibited Notch1 signaling in oligodendrocyte precursors (OPCs) using the Cre/loxP system in transgenic mice to investigate the role of Notch1 in oligodendrocyte (OL) development and differentiation. Early development of OPCs appeared normal in the spinal cord. However, at embryonic day 17.5, premature OL differentiation was observed and ectopic immature OLs were present in the gray matter. At...

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Identifiers

PMID: 12186854
DOI: 10.1083/jcb.200202002
PMCID: PMC2174019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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