Article
Netrin-1 is required for the normal development of spinal cord oligodendrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2006
Tsai Hui-Hsin, Macklin Wendy B, Miller Robert H
Abstract excerpt
Successful CNS myelination is dependent on the correct localization of oligodendrocytes and their interactions with adjacent axons. In the spinal cord, oligodendrocyte precursors originate at the ventral midline and subsequently migrate to the white matter where they mature. In vitro studies suggest this dispersal is mediated by the guidance molecule netrin-1. Here, we show that in the spinal cord of netrin-1...
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