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Article

N-acetyltransferase 2 genotype-related sulfapyridine acetylation and its adverse events.

Biological & pharmaceutical bulletin - 1 Aug 2002

Tanigawara Yusuke, Kita Tomoko, Aoyama Nobuo, Gobara Manabu, Komada Fusao, Sakai Toshiyuki, Kasuga Masato, Hatanaka Hisakatsu, Sakaeda Toshiyuki, Okumura Katsuhiko

Abstract excerpt

Sulfapyridine (SP), one of the metabolites of sulfasalazine (SASP), is further metabolized into N-acetylsulfapyridine (AcSP) by polymorphic N-acetyltransferase 2 (NAT2). NAT2 activity has been diagnosed by phenotyping, that is, evaluating plasma concentrations or urinary excretions of tentatively administered test drugs for dose individualization and avoidance of serious adverse events. Herein, we investigated...

Topics

Acetylation
Adult
Area Under Curve
Arylamine N-Acetyltransferase
Female
Genotype
Humans
Male
Middle Aged
Sulfapyridine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12186410
DOI: 10.1248/bpb.25.1058

Genes

NAT2

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