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Article

N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis.

The American journal of gastroenterology - 1 Jul 2002

Ricart Elena, Taylor William R, Loftus Edward V, O'Kane Dennis, Weinshilboum Richard M, Tremaine William J, Harmsen W Scott, Zinsmeister Alan R, Sandborn William J

Abstract excerpt

OBJECTIVES: 5-Aminosalicylate is metabolized in colonic mucosa by N-acetyltransferase 1 (NAT1), and sulfapyridine is metabolized in the liver by N-acetyltransferase 2 (NAT2). Common genetic polymorphisms in these enzymes result in rapid and slow acetylation. We determined the association between NAT1 genotype and response to mesalamine and sulfasalazine, as well as between NAT2 genotype and toxicity to...

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Source

Identifiers

PMID: 12135032
DOI: 10.1111/j.1572-0241.2002.05838.x

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis.PMID 12135032Read ↗

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NAT1 genotypes do not predict response to mesalamine in patients with ulcerative colitis.Semantic proximity Read ↗

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