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Article

N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulphasalazine in the treatment of inflammatory bowel disease.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie - 1 Mar 2007

Chen Min, Xia Bing, Chen Bixiao, Guo Qiusha, Li Jin, Ye Mei, Hu Zhengguo

Abstract excerpt

AIM: N-acetyltransferase 2 (NAT2) is an important enzyme catalyzing N-acetylation of sulfasalazine (SASP). The aim of the present study was to investigate associations of the genotypes of NAT2 with inflammatory bowel disease (IBD), and with adverse effects of SASP, which is used as the first-line treatment of IBD. PATIENTS AND METHODS: The wildtype allele (NAT2*4) and three variant alleles (NAT2*5B, NAT2*6A and...

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Source

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Identifiers

PMID: 17377643
DOI: 10.1155/2007/976804
PMCID: PMC2657682

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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