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Article

Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer.

Cancer research - 15 Aug 2002

Li Donghui, Walcott Farzana L, Chang Ping, Zhang Weiqing, Zhu Jijiang, Petrulis Elaine, Singletary Sonja E, Sahin Aysegul A, Bondy Melissa L

Abstract excerpt

To test the hypothesis that individual susceptibility to carcinogen exposure is a risk factor for breast cancer, we measured DNA adduct formation in normal breast tissues treated in vitro with 4 micro M benzo(a)pyrene in 76 cancer cases and 60 noncancer controls. We found a significantly higher level of adducts (134.6 +/- 21.2/10(9)) among cases compared with controls (66.9 +/- 7.5; P = 0.007). The level of...

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PMID: 12183407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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