Article
Genetic susceptibility to the development and progression of breast cancer associated with polymorphism of cell cycle and ubiquitin ligase genes.
Carcinogenesis - 1 Sept 2009
Yu Jyh-Cherng, Ding Shian-Ling, Chang Chih-Hao, Kuo Shu-Hsin, Chen Shou-Tung, Hsu Giu-Cheng, Hsu Huan-Ming, Hou Ming-Feng, Jung Lin Yi, Cheng Chun-Wen, Wu Pei-Ei, Shen Chen-Yang
Abstract excerpt
Tumor levels of the cell cycle regulators cyclin E and p27 correlate strongly with survival in breast cancer patients and are specifically regulated by the ubiquitin ligases hCDC4 and SKP2. This study was to explore whether genetic susceptibility to breast cancer is associated with polymorphism of these genes and whether gene-gene and gene-risk factor [i.e. full-term pregnancy (FTP)] interactions are important in...
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