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Oxidative Stress Increases Susceptibility of Mycobacterium tuberculosis to Isoniazid

1 Sept 2002

Abstract excerpt

Isoniazid is a first-line antibiotic used in the treatment of infections caused by Mycobacterium tuberculosis. Isoniazid is a prodrug requiring oxidative activation by the catalase-peroxidase hemoprotein, KatG. Resistance to isoniazid can be obtained by point mutations in the katG gene, with one of the most common being a threonine-for-serine substitution at position 315 (S315T). The S315T mutation is found in...

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PMID: 12183226
DOI: 10.1128/aac.46.9.2765-2771.2002

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