Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An altered Mycobacterium tuberculosis metabolome induced by katG mutations resulting in isoniazid resistance.

Antimicrobial agents and chemotherapy - 1 Jan 2014

Loots Du Toit

Abstract excerpt

The most common form of drug resistance found in tuberculosis (TB)-positive clinical samples is monoresistance to isoniazid. Various genomics and proteomics studies to date have investigated this phenomenon; however, the exact mechanisms relating to how this occurs, as well as the implications of this on the TB-causing organisms function and structure, are only partly understood. Considering this, we followed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Bacterial Proteins
Share to Isoniazid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolome

Share to Mutation

Share to Mycobacterium tuberculosis

Share to Oxidative Stress

Share to Tuberculosis Research and Epidemiology

Source

Open in PubMed Open full text

Identifiers

PMID: 24468786
DOI: 10.1128/AAC.02344-13
PMCID: PMC4023710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An altered Mycobacterium tuberculosis metabolome induced by katG mutations resulting in isoniazid resistance.PMID 24468786Read ↗

Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis.Semantic proximity Read ↗

KatG inactivation generates vulnerabilities in isoniazid resistant strains of <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Biochemical Characterization of Isoniazid-resistant Mycobacterium tuberculosis: Can the Analysis of Clonal Strains Reveal Novel Targetable Pathways?Semantic proximity Read ↗

Altered fatty acid metabolism due to rifampicin-resistance conferring mutations in the rpoB Gene of Mycobacterium tuberculosis: mapping the potential of pharmaco-metabolomics for global health and personalized medicine.Semantic proximity Read ↗

Whole Genome Sequencing and Metabolomic Profiling of Six Clinical Mycobacterium Tuberculosis Isolates Reveal Drug Resistance-Associated Features.Semantic proximity Read ↗

Tuberculosis metabolomics reveals adaptations of man and microbe in order to outcompete and surviveSemantic proximity Read ↗

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Differential Sensitivity of Mycobacteria to Isoniazid Is Related to Differences in KatG-Mediated Enzymatic Activation of the DrugSemantic proximity Read ↗

Oxidative Stress Increases Susceptibility of Mycobacterium tuberculosis to IsoniazidSemantic proximity Read ↗

An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosisSemantic proximity Read ↗

The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis.Semantic proximity Read ↗

Central carbon metabolism remodeling as a mechanism to develop drug tolerance and drug resistance in Mycobacterium tuberculosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.