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Article

Induction of apoptosis by bleomycin in p53-null HL-60 leukemia cells.

International journal of oncology - 1 Feb 2004

Gimonet Delphine, Landais Emilie, Bobichon Helene, Coninx Paul, Liautaud-Roger Françoise

Abstract excerpt

The role of p53 in apoptosis and the contrasting p53 status in tumors prompted us to investigate the bleomycin-induced apoptosis in p53-null human leukemia HL-60 cells (bleomycin at 160 microM for 7.5 h). Cells with apoptotic phenotype increased from 0.87% in controls to 9.40% in bleomycin-treated cells. Both the enzymes, caspase-3 and -8, were activated. Furthermore, the apoptotic phenotypes totally disappeared...

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Identifiers

PMID: 14719107

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BLM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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