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Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells.

PloS one - 1 Jan 2016

Reyes-Zurita Fernando J, Rufino-Palomares Eva E, García-Salguero Leticia, Peragón Juan, Medina Pedro P, Parra Andrés, Cascante Marta, Lupiáñez José A

Abstract excerpt

Maslinic acid (MA) is a natural triterpene present in high concentrations in the waxy skin of olives. We have previously reported that MA induces apoptotic cell death via the mitochondrial apoptotic pathway in HT29 colon cancer cells. Here, we show that MA induces apoptosis in Caco-2 colon cancer cells via the extrinsic apoptotic pathway in a dose-dependent manner. MA triggered a series of effects associated with...

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Identifiers

PMID: 26751572
DOI: 10.1371/journal.pone.0146178
PMCID: PMC4709006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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