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TCL1 participates in early embryonic development and is overexpressed in human seminomas

14 Aug 2002

Abstract excerpt

Overexpression of the TCL1 oncogene has been shown to play a causative role in T cell leukemias of humans and mice. The characterization of Tcl1-deficient mice in these studies indicates an important developmental role for Tcl1 in early embryogenesis. In wild-type embryos, Tcl1 is abundant in the first three mitotic cycles, during which it shuttles between nuclei and the embryo cortical regions in a...

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PMID: 12181493
DOI: 10.1073/pnas.182412399

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