Article
Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression.
Development (Cambridge, England) - 1 Mar 2005
Li Baoan, Nair Mahalakshmi, Mackay Douglas R, Bilanchone Virginia, Hu Ming, Fallahi Magid, Song Hanqiu, Dai Qian, Cohen Paula E, Dai Xing
Abstract excerpt
Previous studies have shown that a targeted deletion of Ovol1 (previously known as movo1), encoding a member of the Ovo family of zinc-finger transcription factors, leads to germ cell degeneration and defective sperm production in adult mice. To explore the cellular and molecular mechanism of Ovol1 function, we have examined the mutant testis phenotype during the first wave of spermatogenesis in juvenile mice....
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