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Article

Reprogramming of Sertoli cells to fetal-like Leydig cells by <i>Wt1</i> ablation

16 Mar 2015

Abstract excerpt

Sertoli and Leydig cells, the two major somatic cell types in the testis, have different morphologies and functions. Both are essential for gonad development and spermatogenesis. However, whether these cells are derived from the same progenitor cells and the mechanism regulating the differentiation between these two cell types during gonad development remains unclear. A previous study showed that overactivation...

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PMID: 25775596
DOI: 10.1073/pnas.1422371112

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