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<i>Wt1</i> deficiency causes undifferentiated spermatogonia accumulation and meiotic progression disruption in neonatal mice

16 Oct 2013

Abstract excerpt

Spermatogenesis is a complex process involving the regulation of multiple cell types. As the only somatic cell type in the seminiferous tubules, Sertoli cells are essential for spermatogenesis throughout the spermatogenic cycle. The Wilms tumor gene, Wt1, is specifically expressed in the Sertoli cells of the mouse testes. In this study, we demonstrated that Wt1 is required for germ cell differentiation in the...

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PMID: 24129152
DOI: 10.1530/rep-13-0299

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