Article
The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients.
Human immunology - 1 Sept 2002
Zheng HongXia, Webber Steven, Zeevi Adriana, Schuetz Erin, Zhang Jiong, Lamba Jatinder, Bowman Pamela, Burckart Gilbert J
Abstract excerpt
Various polymorphisms of the MDR1 gene that encodes for P-glycoprotein (P-gp), a transmembrane pump, have been identified. A silent mutation C3435T in exon 26 and a G2677T mutation in exon 21 have been correlated with P-gp expression and function in humans. The objectives of this study were (a) to determine whether the MDR1 exon 21 and exon 26 polymorphisms were related to steroid weaning in a pediatric heart...
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