Article
Polymorphisms in the DNA repair gene XRCC1 and susceptibility to alcoholic liver cirrhosis in older Southeastern Brazilians.
Cancer letters - 28 Jun 2002
Rossit Andréa Regina B, Cabral Isabel Rosa, Hackel Christine, da Silva Rita, Froes Nívea D T Conforti, Abdel-Rahman Sherif Z
Abstract excerpt
The population of Southeastern Brazil has a very high mortality rate from liver cirrhosis, a disease that is considered an irreversible pre-malignant condition. This is largely due to the high prevalence of alcohol abuse in the region. Chronic alcohol consumption is associated with the production of free radical intermediates that can cause several DNA lesions. Reduced repair of these DNA lesions would,...
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