Article
The X-ray repair cross complementing protein 1 (XRCC1) rs25487 polymorphism and susceptibility to cirrhosis in Brazilian patients with chronic viral hepatitis.
Annals of hepatology - 1 Jan 2000
Almeida Pereira Leite Samantha Therezinha, Marques-Guimarães Nathália, Silva-Oliveira Júlio César, Dutra-Souto Francisco José, Alves-dos-Santos Raquel, Bassi-Branco Carmen Lucia
Abstract excerpt
INTRODUCTION: The progression of hepatic disease in chronic viral hepatitis is accompanied by an increased production of reactive oxygen species (ROS), as well as an accumulation of oxidative DNA damage, which is primarily repaired through base excision repair. XRCC1 (X-ray repair cross complementing protein 1) is one of the most important proteins involved in this repair pathway. The present study was carried...
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