Article
Polymorphisms of XRCC1 gene, alcohol consumption and colorectal cancer.
International journal of cancer - 1 Sept 2005
Hong Yun-Chul, Lee Kwan-Hee, Kim Woo-Chul, Choi Sun-Keun, Woo Ze-Hong, Shin Soo-Kyung, Kim Ho
Abstract excerpt
To evaluate contribution of polymorphisms of the XRCC1 gene to the risk of colorectal cancer, we conducted a case-control study of 209 colorectal cancer cases and 209 age- and gender-matched controls in the Korean population. We tested the hypothesis by constructing allele combinations with known SNP. Allelic variants of the XRCC1 gene at codons 194, 280 and 399 were analyzed in lymphocyte DNA by PCR-RFLP. We...
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