Article
Analysis of the CTLA4 gene in Swedish coeliac disease patients.
Scandinavian journal of gastroenterology - 1 Jan 2002
Popat S, Hearle N, Wixey J, Hogberg L, Bevan S, Lim W, Stenhammar L, Houlston R S
Abstract excerpt
BACKGROUND: A genetic susceptibility to coeliac disease is well established, involving HLA and non-HLA components. CTLA4 is an important regulator of T-cell function and some studies have suggested that sequence variation in the gene might be a determinant of disease susceptibility, although the evidence is conflicting. METHODS: Sixty-two children with biopsy-proven coeliac disease attending a single centre in...
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