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Article

Impact of CYP2D6 Genotype on Paroxetine Serum Concentration.

Therapeutic drug monitoring - 1 Oct 2023

Hole Kristine, Haslemo Tore, Molden Espen

Abstract excerpt

BACKGROUND: Paroxetine is a selective serotonin reuptake inhibitor metabolized by cytochrome P450 (CYP)2D6. Only small-scale studies have reported the impact of CYP2D6 genotype on paroxetine exposure, and international guidelines differ in their recommendations on whether paroxetine should be administered according to CYP2D6 genotype. To clarify this issue, the aim of the present study was to investigate the...

Topics

Humans
Aged
Paroxetine
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP2C19
Genotype
Selective Serotonin Reuptake Inhibitors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37012633
DOI: 10.1097/FTD.0000000000001096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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