Article
The impact of cytochrome P450-2D6 genotype on the use and interpretation of therapeutic drug monitoring in long-stay patients treated with antidepressant and antipsychotic drugs in daily psychiatric practice.
Pharmacoepidemiology and drug safety - 1 Feb 2006
Mulder Hans, Herder Anita, Wilmink Frederik W, Tamminga Wim J, Belitser Svetlana V, Egberts Antoine C G
Abstract excerpt
PURPOSE: This retrospective follow-up study investigates whether cytochrome P450-2D6 (CYP2D6) genotype explains variability in plasma concentrations of psychotropic drugs in daily psychiatric practice. METHODS: The study population consisted of 62 hospitalised psychiatric patients genotyped for CYP2D6. Primary endpoint was the normalised plasma concentration ratio which was defined as the [measured...
Topics
- Antidepressive Agents
- Antipsychotic Agents
- Cytochrome P-450 CYP2D6
- Drug Monitoring
- Female
- Genotype
- Hospitals, Psychiatric
- Humans
- Inpatients
- Length of Stay
- Male
- Middle Aged
- Models, Biological